News

A redundant system requires two MLinks connected to the same switchgear bus. In this configuration the MLinks are synchronized using a redundant link cable.

For more information concerning redundant operation please refer to the MNS iS Interface Manual Redundancy.

MLink is not able to create internal database. Please reboot the MLink. If that doesn’t resolve the problem use MNavigate to download the MLink configuration again.

During startup MLink is checking if all required xml files are available. In case of a missing file that error is indicated. Please use MNavigate to download the MLink configuration again.

MLink is not able to configure the IP settings as mentioned in configuration file e.g. due to wrong setting of Default Gateway parameter for that Ethernet Interface. Please use MNavigate to check the settings and download the MLink configuration again. If a download is not possible please use a flash card reader (ref. to MNavigate Help or MNavigate Manual).

Please check if MLink hardware (the identity number) matches to the project specification (e.g. Profibus MLink <-> Profibus project). Furthermore the DataMapping should be checked. Please use MNavigate to download the MLink configuration or download Mapping file again (ref. to MNavigate Help or MNavigate Manual).

Please use MNavigate to check the redundancy status (Redundancy Report) . If a mismatch was found please download the regarding file. For details please refer to MNavigate Help or MNavigate Manual.

Check if the correct IP address in the address bar of the web browser has been entered.

Check if the MLink is powered on and no fault indication is on the LED indication of MLink.

Check if the Web Server option is activated. This option is customer project specific and can only be enabled using MNS Engineering Tools. If available it can be used to check communication to the MLink.

If the MLink is still not reachable; Remove the CF card from MLink, insert the CF card into a card reader connected to MNavigate and write the MLink data again to the CF card. Ensure that correct address settings are entered for MLink. Re-insert the card to MLink and start MLink and check communication.
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Contenu de ce chapitre

Ce chapitre décrit le stockage, le déplacement et le levage de l’onduleur.

Déplacement de l’onduleur

Pour déplacer l’onduleur, vous pouvez utiliser un palan passé dans les crochets de levage du toit ou un chariot élévateur sous la base de l’onduleur.

L’onduleur doit toujours être déplacé en position relevée.

Stockage de l’onduleur

Stockez l’onduleur dans son emballage de livraison afin de le protéger de tout dommage.

L’onduleur doit toujours être stocké en position relevée. Ne le posez jamais sur le flanc ou le dos

ABB vous recommande de stocker l’onduleur en intérieur, dans un local sec (et chauffé) afin d’éviter toute condensation dans l’appareil.

Si l’onduleur est sorti de son emballage et que de la condensation risque de se former :

Alimentez les résistances de réchauffage internes pour maintenir la température interne de l’onduleur au-dessus de celle du local.

Si vous ne pouvez pas mettre l’appareil sous tension, placez des absorbeurs d’humidité (sachets déshydratants) à l’intérieur de l’onduleur. Utilisez également des absorbeurs d’humidité si l’appareil reste stocké plus de deux semaines sans utilisation des résistances de réchauffage. La dose de produit à utiliser est de 200 g/semaine. Par exemple, pour un stockage de quatre semaine, utilisez 800 g de déshydratant. Remplacez les sachets toutes les quatre semaine et n’ouvrez les portes de l’appareil qu’en cas de nécessité pendant le stockage. Exemples de sachet déshydratant : « Modèle H » de Xdry desiccants ou « Container Dri®IIPole » de Clariant. L’onduleur est livré avec des sachets déshydratants en sortie d’usine. Contactez ABB si la période de stockage doit dépasser deux ans.

Ses entrées et sorties d’air sont scellées. N’ouvrez et ne retirez l’emballage qu’en cas de nécessité.

Un stockage de l’onduleur en extérieur pendant une période prolongée risque d’endommager l’emballage.

Le sol sur lequel repose l’onduleur doit être robuste, plat, sec et exempt de végétation. Il doit fournir un appui homogène à l’onduleur, sans déformations ni contraintes sur le châssis. Ne posez pas l’onduleur directement sur un sol nu afin de protéger la peinture et d’éviter la corrosion.

L’onduleur doit reposer sur des poutres en bois.

Levage de l’onduleur

Avec un palan

• Soulevez l’onduleur dans son carton de transport. Si vous retirez l’emballage, protégez l’onduleur des rayures et des bosses.

• Pour soulever l’onduleur, utilisez les quatre anneaux de levage sur son toit.

• Vérifiez que chaque élingue peut soulever le poids.

• Longueur minimum des élingues : 1,8 m.

• Réglez en longueur les élingues pour éviter tout basculement de l’onduleur.

• Attachez un guide à un coin inférieur de l’onduleur pour l’empêcher de tourner.

Avec un chariot élévateur

• Soulevez l’onduleur dans son carton de transport. Si vous retirez l’emballage, protégez l’onduleur des rayures et des bosses.

• Pour soulever l’onduleur, utilisez les perçages pratiqués à la base de l’appareil.

• Vérifiez que le chariot élévateur peut soulever le poids.

• Quand vous soulevez l’onduleur, son centre de gravité doit se trouver au milieu du dispositif de levage.

• Lors du transport ou du levage de l’onduleur, assurez-vous de ne pas le faire basculer.

• Attention : le centre de gravité de l’onduleur est élevé.

• L’onduleur ne possède pas d’ouverture à écartement standard. Vous devez utiliser un chariot élévateur avec fourche réglable.

• Assurez-vous que les fourches sont assez longues pour soulever l’appareil

Vous devez suivre les consignes ci-dessous à la lettre.

• Transportez l’onduleur dans son carton. Si vous retirez l’emballage, protégez l’onduleur des rayures et des bosses.

• ABB vous recommande d’utiliser un espace fermé ou à l’abri des intempéries (semiremorque, p. ex.) pour le transporter. Si vous transportez l’onduleur sur un plateau ouvert, bâchez-le pendant le transport.
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Description

The 3500/22M Transient Data Interface (TDI) is the interface between the 3500 monitoring system and compatible software (System 1 Condition Monitoring and Diagnostic software and 3500 System Configuration software). The TDI combines the function of a 3500/20 Rack Interface Module (RIM) with the data collection capability of a communication processor such as TDXnet.

The TDI resides in the slot adjacent to the power supplies of a 3500 rack. It interfaces with M series monitors (3500/40M, 3500/42M, etc.) to continuously collect steady state and transient dynamic (waveform) data and pass this data through an Ethernet link to the host software. Refer to the Compatibility section at the end of this document for more information.

Static data capture capability is standard with the TDI. However, using an optional Channel Enabling Disk will allow the TDI to capture dynamic and high-resolution transient data as well. The TDI incorporates the communication processor function within the 3500 rack

Although the TDI provides certain functions common to the entire rack, it is not part of the critical monitoring path and has no effect on the proper, normal operation of the overall monitor system for automatic machinery protection. Every 3500 rack requires one TDI or RIM, which always occupies Slot 1 (next to the power supplies).

I/O Module Signal Common Terminal

Both versions of the TDI I/O Module now include a 2-pin connector for connecting Signal Common to a single point Instrument Ground for the rack. When this is done, the selector switch on the side of the Power Input Module (PIM) must be slid in the direction of the arrow marked “HP” to isolate Signal Common from chassis (safety) ground.

Keyphasor Inputs

Supports the four 3500 system Keyphasor signals. The speed range support is based on the number of dynamic channels enabled:

Supports multiple events per revolution speed inputs up to 20 kHz

Startup/Coastdown Data

Data collected at selected increments of speed and time

Increasing and decreasing speed intervals are independently programmable

Initiation of transient data collection based on detecting the machine speed within one of two programmable windows

The number of transient events that can be collected is only limited by the available memory in the module

Alarm Data Collection

Pre- and post-alarm data

Static values collected at one second intervals for 10 minutes before the event and 1 minute after the event

Static values collected at 100 ms intervals for 20 seconds before the event and 10 seconds after the event

2.5 minutes of waveform data collected at 10-second intervals before the alarm and 1 minute of waveform data collected at 10-second intervals after the alarm

Static Values Data

TDI will collect the static values including the values measured by the monitors.

TDI provides four nX static values for each point. Amplitude and phase are returned for each of the values.

Waveform Sampling

Collection of waveforms for 48 channels.

DC-coupled waveforms

Simultaneous Synchronous and Asynchronous data sampled during all operational modes

User-configurable Synchronous waveform sampling rates:

o 1024 samples/rev for 2 revolutions

o 720 samples/rev for 2 revolutions

o 512 samples/rev for 4 revolutions

o 360 samples/rev for 4 revolutions

o 256 samples/rev for 8 revolutions

o 128 samples/rev for 16 revolutions

o 64 samples/rev for 32 revolutions

o 32 samples/rev for 64 revolutions

o 16 samples/rev for 128 revolutions

Asynchronous data sampled to support an 800-line spectrum at the following frequency spans:

quency spans:

o 10 Hz

o 20 Hz

o 50 Hz

o 100 Hz

o 200 Hz

o 500 Hz

o 1000 Hz

o 2000 Hz

o 5000 Hz

o 10 kHz

o 20 kHz

o 30 kHz

Asynchronous data is anti-alias filtered

Channel Pairs for providing Orbit or synchronous full spectrum presentations can be split among multiple monitors. For asynchronous full spectrums the channels must be within a monitor channel pair (30 kHz frequency span data will not be phase correlated between channel pairs)

1. Main Module

2. 10 Base-T/100 Base TX (copper) Ethernet I/O Module

3. 100 Base-FX (fiber optic) Ethernet I/O Module

4. LEDs indicate operating status of the module

5. Hardware Switches

6. USB Configuration Port for configuring or retrieving

machinery data

7. OK Relay indicates the OK status of the overall rack

8. Signal Common external grounding terminal

9. RJ-45 Ethernet Port for configuration and data collection

10. System Contacts

11. Fiber Optic Ethernet Port for configuration and data collection
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Key Points

The number of canceled sailings of freight vessels out of China is picking up as ocean carriers attempt to manage a pullback in orders due to the trade war and tariffs.

A steep decline in containers being shipped to the U.S. will have a big impact on the supply chain, from port to trucking, rail and warehouse economics.

“We won’t go to zero containers, but we will see a decrease in containers and as a result, in the future we will see a massive raft of blank sailings announced,” one freight expert tells CNBC.

Aerial view of the import and export container terminal of Longtan Port on December 26, 2024 in Nanjing, Jiangsu Province of China.

China News Service | China News Service | Getty Images

U.S. importers are being notified of an increase in canceled sailings by freight ships out of China as ocean carriers try to balance the pullback in orders resulting from President Trump’s tariffs and the escalation of tensions in the trade war.

A total of 80 blank, or canceled, sailings out of China have been recorded by freight company HLS Group. It wrote in a recent note to clients that with the trade war between China and the U.S. leading to a demand plummet, carriers have started to suspend or adjust transpacific services.

Major ocean freight alliance ONE has “suspended until further notice” a route it had previously been planning to bring back in May, which would include ports of Qingdao, Ningbo, Shanghai, Pusan, Vancouver, and Tacoma. Meanwhile, an existing route is planning to cancel its port call at Wilmington, North Carolina.

The impact of the diminished freight container traffic to North America will be significant for many links in the economy and supply chain, including the ports and logistics companies moving the freight. If each sailing was carrying 8,000 to 10,000 TEUs (twenty-foot equivalent units), that would equal a decline in freight traffic of between 640,000-800,000 containers, and lead to decreased crane operations at the ports, lower fees that could be collected, and declines in container pick-ups and transports by trucks, rails, and to warehouses for storage.

The World Trade Organization warned on Wednesday that the outlook for global trade has “deteriorated sharply” in the wake of Trump’s tariffs plan. JB Hunt shares hit their lowest level since November 2020 after commentary during the trucking company’s earnings call about the uncertainty from tariffs.

“We have no way of knowing how significant this drop in orders will be on vessel schedules,” said Alan Murphy, CEO of Sea-Intelligence. “There are no models to extrapolate this. What I can tell you is the majority of containers on the vessels servicing the Asia to U.S. trade routes is China. We won’t go to zero containers, but we will see a decrease in containers and as a result, in the future, we will see a massive raft of blank sailings announced.”

China accounts for approximately 30% of all U.S. containerized imports (down from 37% in 2018), but accounts for approximately 54% of all U.S. containerized imports from Asia (down from 67% in 2018).

Bruce Chan, director of global logistics & future mobility for Stifel, said the tariff policy has created significant uncertainty with respect to consumer demand, and retailers have been positioning their businesses conservatively with inventory, especially given “scar tissue” from the recent overstock after the post-Covid supply chain squeeze from 2021-2022. “That uncertainty is beginning to manifest in blanked container ship sailings on core eastbound transpacific lanes, in our view, opening the potential for a double-digit decline in inbound containerized imports as early as next month,” he said.

Booking volumes from the last week of March to first week of April across global and U.S. trade lanes plummeted. There were sharp decreases in bookings across several categories, including apparel & accessories; and wool, fabrics & textiles, both down over 50%. Major product categories from China that are moved in containers include apparel, toys, furniture, and sports equipment, all of which are subject to steep tariffs.

As a result of the decrease in containers, ocean carriers will not only cancel vessels, but also adjust or cancel vessel routes commonly called “vessel strings,” such as the ONE service from China to Vancouver and Tacoma. These routes dedicating vessels to move the ocean freight at specific ports take months of planning. The elimination of vessels also impacts U.S. exports bound for Asia and relying on ships traveling in both directions.

Ocean carriers need to move full vessels to generate a return on investment, but it is not in their best interest to use large vessels if they cannot be filled. To ensure vessels are used at full capacity, carriers have a number of ways to alter the vessel strings. Stretching out ship arrivals by canceling sailings is an option for container volume to better match capacity. According to Murphy, 99% of vessel services are weekly and it takes a vessel approximately seven weeks to make a round trip.

“During Covid, ocean carriers parked their vessels for maintenance,” Murphy said. “Ocean carriers can also blank (cancel) a sailing, omit vessel strings entirely, use smaller vessels, or slow steam the vessels where they are traveling longer.”

These measures will cut the available vessel capacity for containers, according to Murphy, which helps remaining ships to be filled, with uncertain implications for overall pricing in the ocean freight business. While a decline in sailings could lead to a drop in prices, during Covid, blank sailings were identified by shippers around the world as a reason for container rates that spiked as high as $30,000. In that case, shippers say the ocean carriers canceled sailings for longer than needed.

Vietnam continues to gain on China

The global supply chain demand and pricing situation remains fluid and subject to sharp short-term swings tied to tariffs policy. As Chinese trade comes under strain, a key metric in ocean freight rates shows Vietnam surging in early April.

The “mid-low” ocean rates, which represent the costs of shipping goods for a larger-sized shipper on a particular ocean route, have jumped by 43% since March 30 for Vietnam. Xeneta calculates the market mid-low and market mid-high segments by looking at the values of the 25 and 75 percentiles of a trade lane rate.

“The fact that the lower end of the market has been rising shows the heat is on,” said Peter Sand, chief analyst at Xeneta. He said that is continuing after Trump’s decision to pause what he called “reciprocal” tariffs on countries other than China for 90 days.

“Shippers large and small all have to pay up for frontloading, as the ‘pause’ made the pulling forward of freight possible again,” Sand added.

This demand from U.S. shippers importing goods can be seen in the increase in container shipping spot rates on the Ho Chi Minh City to Los Angeles ports route, jumping by 24% going into April.

According to data compiled by Xeneta for 2025, the spread between China’s largest container port, Shanghai, and Vietnam’s largest container port, Ho Chi Minh City, has also narrowed per forty-foot equivalent unit (FEU) for shipments to the ports of LA and Long Beach.

Even with increased costs for shippers, they will continue to bring in imports from non-China nations because the situation remains highly unpredictable, Sand said. “There is every possibility the higher tariffs come into effect 90 days from now or even at an earlier stage,” he added.
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The Central Conference on Neighboring Work was held in Beijing from April 8 to 9. Xi Jinping, General Secretary of the CPC Central Committee, President of the State, and Chairman of the Central Military Commission, attended the meeting and delivered an important speech, systematically summarizing the achievements and experience of my country’s neighboring work since the new era, scientifically analyzing the situation, and clarifying the goals, tasks, ideas and measures of neighboring work in the future period.

General Secretary Xi Jinping’s important speech aroused enthusiastic response among the delegates. Based on their work reality, they talked about their learning experience and implementation plans of the spirit of the meeting, and expressed that they would thoroughly implement the requirements put forward in the General Secretary’s important speech, focus on building a community of shared future for the surrounding areas, and strive to create a new situation in neighboring work.

In 2013, at the first symposium on neighboring diplomacy since the founding of the People’s Republic of China, General Secretary Xi Jinping proposed the concept of neighboring diplomacy of being friendly, sincere, beneficial and accommodating, leading China to open up a new realm of friendly cooperation with neighboring countries. Over the past decade, neighboring work has achieved historic achievements and undergone historic changes. Today, China has reached a consensus on building a community of shared future with 17 neighboring countries, forming “two major clusters” of communities of shared future in the Indochina Peninsula and Central Asia.

“China has always placed its neighboring diplomacy at the top of its overall diplomatic agenda, and ASEAN is the priority of China’s neighboring diplomacy.” Chinese Ambassador to Malaysia Ouyang Yujing said that under the joint leadership of General Secretary Xi Jinping and Malaysian leaders, China and Malaysia have reached an important consensus on building a community with a shared future, and have achieved fruitful cooperation results in the fields of politics, economy, trade, and cultural exchanges. China-Malaysia cooperation is a microcosm of China-ASEAN cooperation. “Under the strategic guidance of the leaders of the two countries, China-Malaysia relations will surely reach a new level, and China-ASEAN cooperation will also open up a new situation.”

Building a “Central Asian Cluster” of comprehensive strategic partners, establishing the China-Central Asia mechanism, and promoting the great development of the SCO… Han Chunlin, Chinese Ambassador to Kazakhstan, said that the historic leap and historic achievements in China’s relations with Central Asian countries are fundamentally due to the scientific guidance of Xi Jinping’s diplomatic thought and the leadership of General Secretary Xi Jinping. General Secretary Xi Jinping proposed major concepts and propositions such as building a community with a shared future for mankind, the global development initiative, the global security initiative, and the global civilization initiative, which provided important conceptual guidance for the development of the China-Central Asia mechanism and the SCO.

The meeting pointed out that my country’s current relations with its neighbors are in the best period since modern times, and it has also entered an important stage of deep linkage between the surrounding pattern and the world’s changes. my country has a vast territory and a long border. The surrounding areas are an important foundation for achieving development and prosperity, a focus for maintaining national security, a priority for managing the overall diplomatic situation, and the key to promoting the building of a community with a shared future for mankind. We must examine the surrounding areas with a global perspective and enhance our sense of responsibility and mission in doing a good job in the surrounding areas.

“The world today is full of chaos and the century-old changes are accelerating. Many countries have fallen into unrest or even war. In contrast, China has a harmonious political environment, people live and work in peace and contentment, and the economy has stabilized and improved. The Party Central Committee with Comrade Xi Jinping as the core has taken charge of the overall situation, maintained a high degree of strategic determination, and responded to various challenges firmly and steadily. This is the greatest confidence for us to do a good job in diplomacy, and it is also the fundamental reason why China is highly respected on the international stage and its international influence is increasing.” Ambassador Fu Cong, China’s permanent representative to the United Nations, said that we must unswervingly implement the concept of a community with a shared future for mankind, continuously promote the reform and improvement of global governance, and safeguard the interests of the vast number of developing countries.

Jiang Zaidong, Chinese Ambassador to Pakistan, said that General Secretary Xi Jinping proposed the “Belt and Road” initiative, which showed the broad world sentiment of the leader of a big party and a big country. The China-Pakistan Economic Corridor is a pilot project of the Belt and Road Initiative. It has attracted more than 25 billion US dollars in direct investment and created more than 230,000 jobs. It has not only improved the level of China-Pakistan cooperation, but also promoted Pakistan’s economic and social development. We will continue to promote high-quality joint construction of the Belt and Road Initiative in accordance with the deployment of the General Secretary, and make greater contributions to promoting the building of a community with a shared future for mankind. At the same time, we will thoroughly implement the overall national security concept and effectively safeguard the security of overseas interests.

“In Mongolia, where I work, many people have never forgotten the invitation issued by the General Secretary to “take the express train of China’s development” and are happy to talk about the General Secretary’s statement that “one flower blooms but not spring, a hundred flowers bloom and spring fills the garden.” China-Mongolia relations are a vivid portrayal of China’s sharing of breath and destiny with its neighboring countries.” Shen Minjuan, Chinese Ambassador to Mongolia, said that the 21st century must be the Asian century, and China’s neighboring diplomacy must have great potential. We must adhere to Xi Jinping’s diplomatic thought as the fundamental guideline, seek progress in stability, keep the right path and innovate, and constantly create a new situation in neighboring work, so that Asia will continue to be a stable plate and a highland of development, and serve the Chinese-style modernization construction, the construction of a strong country, and the great cause of national rejuvenation.

Ambassador Hou Yanqi, head of the Chinese Mission to ASEAN, said that China and ASEAN are geographically adjacent and culturally connected. They have established a comprehensive strategic partnership and have been each other’s largest trading partners for five consecutive years. China and ASEAN belong to the global South and both advocate Asian values ​​and respect the diversity of civilizations. ASEAN recognizes China’s development path and philosophy and believes that China is an indispensable partner for all countries to achieve modernization. China firmly supports ASEAN in maintaining the central position of the regional cooperation framework, and promotes ASEAN to establish close ties with the Shanghai Cooperation Organization, BRICS, etc., jointly practice true multilateralism and open regionalism, and jointly safeguard international fairness and justice and the interests of the vast number of developing countries. We will fully and thoroughly implement the spirit of General Secretary Xi Jinping’s important speech, promote the building of a closer China-ASEAN community of shared future, and create a more favorable surrounding environment for the comprehensive promotion of Chinese-style modernization.

Recently, the United States has abused tariffs on all trading partners, including China, seriously infringed on the legitimate rights and interests of all countries, seriously violated the rules of the World Trade Organization, seriously damaged the rules-based multilateral trading system, and seriously impacted the stability of the global economic order, causing strong opposition from the international community, including countries around China.

The delegates said that open cooperation is a historical trend, and mutual benefit and win-win are what people want. We must stand firmly on the right side of history and the progress of human civilization and, together with neighboring countries, resolutely oppose the idea that “might is right” and jointly safeguard international fairness and justice and the legitimate rights and interests of all countries.
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On April 11, according to media reports, some experts pointed out that the tariff dispute is limited. As long as the tariff is increased to 60%-70%, it is actually no different from increasing it to 500%, and no business can be done.

He also pointed out that since the United States is an unreliable and selfish image, China must show rationality and fairness. We continue to remain open, and everyone will naturally have a choice.

Analysts believe that in order to cope with the US tariffs, US retailers may need to increase prices by 10% to 12%. The tariffs will also push up the prices of mobile phones, TVs and other products, and suppress the US electronic product consumer market.

In this tariff storm, Apple has been hit the most. Recently, many institutions have lowered their target prices for Apple. Among them, Morgan Stanley lowered Apple’s target price from US$252 to US$220 and maintained its overweight rating. Goldman Sachs lowered Apple’s target price from US$294 to US$242 and maintained its buy rating.

If Apple chooses to fully pass on the costs brought by tariffs to consumers, the price of Apple phones is expected to increase by 30%-40%.
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Key Points

Isomorphic Labs was spun out of Google DeepMind, after the tech giant achieved one of the biggest biological breakthroughs in the last 50 years.

Demis Hassabis is at the helm of both Isomorphic and DeepMind, the Google division at the forefront of the search company’s efforts to compete in the tech industry’s AI race.

On Wednesday, Isomorphic and Google DeepMind made AlphaFold3 available to the scientific community, for non-commercial use.

With a fresh $600 million, Isomorphic is setting out to achieve its ultimate goal: to “solve all disease” through AI-powered drug discovery.

Demis Hassabis, Co-Founder and CEO of Google DeepMind and Nobel Prize Laureate in Chemistry 2024, attends the Artificial Intelligence (AI) Action Summit at the Grand Palais in Paris, France, February 10, 2025.

Benoit Tessier | Reuters

On a rare sunny day in London at the Google DeepMind office, Colin Murdoch saw the bank deposit from his employer come through.

It wasn’t his paycheck. Google was investing in his startup.

The fledgling company was Isomorphic Labs, the secretive artificial intelligence life sciences startup spun out of Google DeepMind after one of the biggest biological breakthroughs in the last 50 years. The check came in November 2021, and Murdoch was on the founding team.

As DeepMind’s chief business officer, Murdoch was tasked with finding business applications for DeepMind’s innovations in AI research. With Isomorphic, Murdoch wanted to zero in on the possibilities of AlphaFold2, an AI system with the capability of predicting the structures of proteins.

The viral program was developed by DeepMind in 2020 and helped solve a mystery that had flummoxed biologists for 50 years. If applied correctly, it had the potential to find new treatments for diseases like Alzheimer’s, Parkinson’s and cancer. The system would go on to win a Nobel Prize in chemistry.

It also helped Murdoch, and Isomorphic’s founder Demis Hassabis, decide on an ultimate goal: to “solve all disease” through AI-powered drug discovery.

“When AlphaFold came along, I think Demis and I looked at this and we thought, ‘Well, what could we do with AlphaFold?’” Murdoch, now Isomorphic’s president, told CNBC in an interview by video chat. “Really, that was a signal that we could begin to apply AI in this world of drug discovery.”

Hassabis remains with Isomorphic as CEO, and is simultaneously running DeepMind, the Google division at the forefront of the search company’s efforts to compete in the tech industry’s ongoing AI race. While Isomorphic is an independent unit of Google parent Alphabet, Hassabis’ dual roles reflect the intertwined relationship between the two parties.

Isomorphic has never revealed how much Google initially invested in 2021. But last month, the company locked down its first external funding in a $600 million round led by Thrive Capital with participation from GV, formerly known as Google Ventures, as well additional capital from Alphabet. With its fresh capital, Isomorphic plans to expand into biologics and to add compute to power its work in AI.

The drug discovery market is expected to reach $71 billion in value by 2025 as AI continues to change the industry.

On average, it can take anywhere between 10 and 15 years — and sometimes more than $2 billion — for a drug to make it from the bench to final approval from the Food and Drug Administration. It also costs hundreds of millions of dollars to conduct clinical trials on potential new drugs. For drugs that fail those trials, that’s a sunk cost. But using AI in drug discovery could make the process more efficient and less costly, leading to more successful drugs that make it to market.

Since its founding, Isomorphic has grown to more than 200 people and has established partnerships with Eli Lilly and Novartis, two of the world’s largest pharmaceutical companies. They pay Isomorphic, in part, to help make sure their long-term bets pay off down the line. The two partnerships include both upfront and milestone payments and “have the potential to be worth nearly $3 billion to Isomorphic Labs,” per the company, minus potential royalties resulting from future drug sales.

Google DeepMind and Isomorphic on Wednesday made AlphaFold3 available to the scientific community, for non-commercial use. The system can “predict the structures of and interactions between all life’s molecules,” Isomorphic said. “This goes beyond predicting proteins to DNA, RNA, and ligands and much more which is important for advancing drug discovery and biological understanding.”

Using AI to ‘solve’ disease

Murdoch, 46, wanted to be a doctor growing up, but his squeamishness led him to abandon the idea in favor of tech and engineering. DeepMind’s research into protein structures rekindled his interest in medicine.

The announcement of AlphaFold2 in 2020 — a step up from the initial version in 2018 — took the life sciences world by storm. That’s because proteins are one of the main building blocks of the cell, driving all chemical reactions that make up life as we know it. Whichever shape they fold into, of virtually infinite possibilities, decides their function.

If you can predict a protein’s shape, you can predict its function, and since research suggests that many diseases are influenced by incorrectly folded proteins, the research made waves.

Shortly after AlphaFold2′s release, Murdoch and Hassabis assembled a group of DeepMind employees to explore the ways the AI system could be put to use. After several months, they identified areas where they thought AI could make a difference in drug discovery, and put together a business plan for Isomorphic that they pitched to Alphabet.

The Google parent “thought it was a phenomenal idea,” Murdoch said.

Colin Murdoch, Chief Business Officer, DeepMind, on Centre Stage during day one of Web Summit 2022 at the Altice Arena in Lisbon, Portugal.

Eóin Noonan | Sportsfile | Getty Images

Alphabet decided to spin off Isomorphic from DeepMind, tasking the startup with using the AlphaFold technology to deliver biomedical breakthroughs and advance drug design programs.

In early 2022, the team was made up of just over a dozen people, working out of a temporary office space in King’s Cross, London’s tech hub.

Since then, Isomorphic has been operating in quasi-stealth mode, keeping mostly quiet about its work and advancements. In recent years, representatives for Isomorphic have said the company wasn’t “quite ready to share our progress yet,” and that executives were shying away from media interviews as the company built its technology and added talent.

The DeepMind employees who had been working on Isomorphic didn’t all stay after the spinout. Hassabis and Murdoch had to hire a team from scratch. They started with the C-Suite: a chief technology officer, chief AI officer, chief scientific officer and chief people officer. From there, they hired experts in therapeutics and machine learning.

“We’ve put a huge amount of energy and effort into building what we call an interdisciplinary culture that combines these two sorts of expertise,” Murdoch said. “That blend of AI and drug discovery expertise is absolutely essential to doing what we’re doing.”

Chess prodigy, knight and AI ‘rockstar’

Hassabis, 48, is one of the most important people at Google.

He co-founded DeepMind in 2010 with the goal of building “general-purpose” AI, and he sold the startup to Google in 2014, reportedly for between $400 million and $650 million. DeepMind served as one of Google’s key AI research divisions for years.

But that was upended in late 2022, when OpenAI released its ChatGPT chatbot, ushering in the age of generative AI and forcing Google to step on the accelerator.

DeepMind and Hassabis’ importance within Google have only risen since.

Google merged DeepMind with Google Brain, another AI research unit at the search company, to become Google DeepMind in April 2023. Hassabis was tapped to lead the combined division. More power shifted his way last October, when the Gemini app, which includes Google’s direct-to-consumer AI products, was moved under the Google DeepMind umbrella.

Through the drastic changes at DeepMind since 2023, Hassabis has continued in his other CEO role at Isomorphic.

“All the AI talent that’s at the company, led by Demis, they have cutting-edge research talent, [and] a lot of these folks could go work at any AI lab — it didn’t have to be a bio-focused one,” said Vince Hankes, a partner at Thrive Capital.

Hankes calls Hassabis “an extraordinarily special entrepreneur.”

People who have known Hassabis for years describe him the way they would a celebrity, expressing awe, respect and a slight air of incredulity that he knows who they are. He’s a chess prodigy, a Nobel Prize winner and, as of 2023, a knight — Sir Demis Hassabis.

Nobel laureate in Chemistry Demis Hassabis receives his award from Sweden’s King Carl Gustaf at the Nobel Prize ceremony in the Konserthuset in Stockholm, Sweden December 10, 2024.

Pontus Lundahl | TT | Via Reuters

Krishna Yeshwant, GV managing partner, said meeting Hassabis at Oxford University years ago was like “meeting a rockstar.” Already, Hassabis’ accomplishments were well known, but he remained approachable and didn’t resort to jargon to talk about his work in AI.

“Before DeepMind was acquired, even back then, he was thinking with a mindset towards breakthroughs,” Yeshwant said.

GV invested in Isomorphic because of the startup’s strength in both AI and therapeutics. Although GV invests across many areas of tech and biotech, Isomorphic struck Yeshwant as unique because of how Hassabis thinks.

“In biotech, you run these experiments, and sometimes experiments don’t work, and sometimes they do. And when they do, you move humanity forward in some way,” Yeshwant said. “In tech, it’s not always set up that way. It’s often, ‘Did we sign the next customer? Did we develop this feature?’”

“It’s unusual to see a person taking somewhat of that same [biotech] approach in technology,” Yeshwant said. “Demis, to his credit, has been doing it that way for a long time.”

Hassabis told CNBC in a statement that he believes improving human health is one of the most important use cases for AI.

“We’ve got this amazing tool that could finally unlock some of the biggest mysteries around disease and help us overcome them,” Hassabis said in the statement. “The idea of a future where people are healthier for longer, that’s what really excites me.”

Expanding operations and adding compute

Now that Isomorphic is beginning to open up, the startup says it plans to use its first external funding to expand into the field of biologics.

Currently, Isomorphic can use its general-purpose engine to design small-molecule drugs quickly — imagine a pill that you can take as a treatment — but the expansion into biologics opens up the potential range of diseases that the startup will be able to tackle, since biologics are typically injections rather than pills, Murdoch said.

“We’re primarily focused on cancer and immunology with our own internal programs, and so we’ll be able to take those further, run those faster and add programs,” Murdoch said.

Isomorphic will also focus on finding use cases for AlphaFold3.

The company’s new funding will also be used for compute a major issue in the AI space, where companies need all the graphics processing units (GPUs) they can access. Isomorphic will need to build more models to run at a greater scale with more data attached, both on the AI and therapeutics side.

“It’s expensive to build a full-stack life science company — and this one, they have to invest in compute, they have to invest in talent, they’ve got to invest in data, they’ve got to invest in developing assets,” Thrive’s Hankes said.
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DETROIT — General Motors on Thursday unveiled an $80,000 all-electric Cadillac Lyriq performance version as the Detroit automaker aims to become the best-selling luxury electric vehicle brand in the U.S. this year.

Cadillac hopes to achieve that goal with an expanding lineup of electric vehicles, such as the high-performance Lyriq-V, Escalade IQ SUV and the upcoming entry-level Optiq crossover.

“We will position Cadillac as the best-selling luxury electric vehicle brand in the U.S. in 2025. Let me repeat that: the best-selling luxury electric vehicle [brand] in 2025,” Cadillac Vice President John Ross said at a news conference. “There’s no limit to what we can do in the luxury electric vehicle space.”

But the “luxury” space may not be as clear-cut as it seems. Cadillac said after Ross’ comments that it won’t include Tesla in its lineup Cadillac is positioning itself as a “luxury” automaker, even though some of its products are priced in the same ballpark as some of its rivals. A brand spokesman said Cadillac lists brands such as Audi and Mercedes-Benz as its core competitors.

“There are a few models in the Tesla lineup that may fit the luxury positioning, but they still incorporate some interesting elements into the brand,” Ross said.

In addition to Tesla, which is far ahead in the US electric vehicle market, Cox Automotive reported that Cadillac sold nearly 30,000 electric vehicles last year, just behind BMW’s approximately 51,000. Audi and Mercedes-Benz also have sales close to Cadillac. In contrast, Cox estimates that Tesla sold more than 633,000 electric vehicles in the United States last year.

Historically, the auto industry has been made up of “mainstream” brands such as Chevrolet and luxury brands such as Cadillac. But today, many brands, including Cadillac and Tesla, offer vehicles across a wide range of prices.

Tesla’s pricing ranges from about $42,500 for the Model 3 sedan to about $100,000 for vehicles like the Cybertruck and Model S Plaid. By comparison, Cadillac’s electric vehicles, once available, are expected to range in price from $54,000 for the Optiq to more than $150,000 for the Escalade IQ. Cadillac also offers a custom car, the Celestiq, for more than $300,000.

For reference, Kelley Blue Book reports that the average transaction price for a new electric vehicle was $55,544 at the end of last year. That doesn’t include consumer EV incentives, such as a federal tax credit of up to $7,500.

Cadillac expects to have five electric vehicles on the market by the end of the year, compared to three currently. That would put it on par with Tesla’s number of electric vehicles, but Tesla’s share of the U.S. electric vehicle market was still estimated to be close to 50% last year

As for the Lyriq-V, Cadillac says it will have about 615 horsepower, 650 foot-pounds of torque and a 285-mile range on a full charge. 0-60 mph acceleration is expected to be as fast as 3.3 seconds.

The Lyriq is Cadillac’s first mass-produced electric vehicle and is included in its high-performance V-Series model. The Lyrq-V is generally similar to the regular model but includes unique badging and enhanced performance parts and other accessories to improve driving dynamics.

GM says the Lyriq-V will start at $79,995 and will be sold in the U.S., Canada and other countries, with production to begin in early 2025 at GM’s Spring Hill manufacturing plant in Tennessee.
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